백서 두개골 결손부의 골재생에 fibrin glue가 미치는 영향에 관한 실험적 연구
The experimental study for influence of fibrin glue during healing phase after making artificial bone defect
임재석, 장현석, 윤정주, 이의석, 박은용, 서제덕,
소속 상세정보
임재석 ( Rim Jae-Suk ) - 고려대학교 의과대학 구강악안면외과학교실
장현석 ( Jang Hyon-Seok ) - 고려대학교 의과대학 구강악안면외과학교실
윤정주 ( Yun Jung-Ju ) - 고려대학교 의과대학 구강악안면외과학교실
이의석 ( Lee Eui-Seok ) - 고려대학교 의과대학 구강악안면외과학교실
박은용 ( Park Eun-Yong ) - 고려대학교 의과대학 구강악안면외과학교실
서제덕 ( Suh Je-Duck ) - 서울대학교 보라매병원 구강악안면외과학교실
KMID : 0360120050270050431
Abstract
Fibrin glue is composed of fibrinogen and thrombin and used in various regions for multiple use. Basic principle is that thrombin converts fibrinogen to fibrin in the presence of Ca2+. The structure of fibrin is loose at the beginning, but after about 5 minutes a tight structure is formed under the influence of factor VIII which changes fibrin monomer into fibrin polymer. Fibrin glue is used for tissue adhesive, suture, local hemostasis, wound healing, closure of subdural space. Fibrin adhesive has been used in oral and maxillofacial surgery for hemostasis after tooth extraction in patients with coagulation disorders, skin graft fixation, reattachment of periodontal flaps, in combination with autogenous bone chips to fill the bony cavities following cyst removal, and for securing the hydroxyapatite granules for maxillary alveolar ridge augmentation. This study was designed for researching influence of fibrin glue during healing phase after making artificial bone defect.
키워드
Fibrin glue;Rat;CSD
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